Evidence of Impact

Below you will find a list of resources where you can learn more about GxAlert technology and how it's having a disruptive impact on TB programs worldwide. Click graphics below to view complete research document or presentation. 

Overview:

Impact on reporting rates and time to diagnosis:

Connectivity, if skillfully implemented and appropriately utilized, can have a dramatic positive effect on time to treatment, improving patient outcomes and helping to minimize the spread of disease (see article by Natasha Gous 2018)

  • In Malawi, paper-based laboratory diagnostic reporting has, on average, a 5%-20% loss in results between the laboratory and clinic. Digital reporting has shown 0% loss of results. For the 15,000 patients in our pilot in Malawi, this means 3,000 patients who weren’t “lost.” (See 2018 CROI poster)
  • In Malawi, paper-based reporting of HIV viral load results take an average of 22 days from test completion in the central lab to result receipt at the peripheral clinic. Introduction of our connectivity solution significantly decreased this reporting interval by 94%, from 22 days down to 1 day. This allowed clinicians to identify abnormal results, initiate adherence counselling and switch patients to second line treatment within 1 day of results being available at the laboratory. (See 2018 CROI poster)
  • Uganda has shown major improvements in TB reporting rates from GeneXpert testing sites due to the introduction of the GxAlert connectivity solution; 35% reporting from GeneXpert sites in 2016 (prior to connectivity) to 100% reporting from sites post-connectivity (Sama et al, Union 2017- not available online).

In Nigeria, SystemOne’s connectivity platform GxAlert is being used to reduce the turnaround time for reporting of GeneXpert Rifampicin-resistant TB cases to the TB government supervisor, state program manager and national program enrollment officer through automated SMS alerts. Since implementation of the GxAlert SMS system, the proportion of drug-resistant TB patients on treatment has significantly increased from 20% in 2014 to 85% in 2015 (2015 Union oral presentation; article by Mustapha; 2017 Health Finance poster)

Impact on program and fleet management:

Our solutions provide insights into laboratory workflow and workload to ensure optimal use of instruments, assays and shift-workers, error rates, stock-outs and over-stocking of facilities, improving ROI of the instruments and investments in assays/tests.

  • By monitoring instrument error rates and error codes centrally, the Ethiopian Public Health Institute has been able to identify sites with high errors and intervene through on-site troubleshooting and refresher training. Since the adoption of GxAlert, national unsuccessful test rate (errors, invalids, no results) have steadily decreased by 6% (Mengesha et al, Union Africa 2017 - not available online).  
  • Due to the real-time monitoring and immediate feedback provided on the GxAlert system, Bangladesh had decreased their national instrument error rates by 46%; from 6.09% (2015) to 2.81% (2017) (Hossain et al, submitted to Union Oct, 2018).
  • Bangladesh is utilizing GxAlert to improve the utilization of machines. The local device distributor and servicing company can now remotely monitor the module status (failures) and take preventive actions, which has led to a significant drop in module replacement time from 5-14 months in 2015 to only 2 weeks in 2017 (Hossain et al, submitted to Union Oct, 2018).
  • Based on a 5-country study, SystemOne estimates that 40%-60% of cartridges go to waste because they are unused or expired. Some labs run out of cartridges while others have unused inventory that could be used elsewhere. Since management of inventory on GxAlert, Bangladesh has experienced no stock outs of GeneXpert inventory (Hossain et al, submitted to Union Oct, 2018).

White PaperS:

  February 2018: SystemOne White Paper |  "Cost Benefits of Diagnostic Connectivity"

February 2018: SystemOne White Paper | "Cost Benefits of Diagnostic Connectivity"

 
 

RESEARCH & PUBLICATIONS:

  April 2018 | Expert Reviews in Molecular Diagnostics:   The impact of digital technologies on point of care diagnostics in resource limited settings. 

April 2018 | Expert Reviews in Molecular Diagnostics:  The impact of digital technologies on point of care diagnostics in resource limited settings. 

  October 2016 |  Remote monitoring of Xpert MTB/RIF testing in Mozambique: results of programmatic implementation of GxAlert

October 2016 | Remote monitoring of Xpert MTB/RIF testing in Mozambique: results of programmatic implementation of GxAlert

  2016 | Masters Thesis:  Effects of GeneXpert MTB/RIF Testing and GxAlert eHealth Platforms on MDR-TB Diagnosis and Linkage to Care in Sofala Province, Mozambique

2016 | Masters Thesis: Effects of GeneXpert MTB/RIF Testing and GxAlert eHealth Platforms on MDR-TB Diagnosis and Linkage to Care in Sofala Province, Mozambique

  July 2016 | ERJ Express : Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better?

July 2016 | ERJ Express: Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better?

  2015 |  Implementing rapid testing for tuberculosis in Mozambique

2015 | Implementing rapid testing for tuberculosis in Mozambique

  March 2016 | The Union:  Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination.

March 2016 | The Union: Connectivity of diagnostic technologies: improving surveillance and accelerating tuberculosis elimination.

  September 2014 | Moses Joloba:  Introduction of GxAlert in Uganda

September 2014 | Moses Joloba: Introduction of GxAlert in Uganda

  2016: GLI  Quick Guide to TB Diagnostics Connectivity Solutions   

2016: GLI Quick Guide to TB Diagnostics Connectivity Solutions

 

   March 2018 | International Union Against TB & Lung Disease:  Unsuccessful Xpert® MTB/RIF results: the Nigerian experience


March 2018 | International Union Against TB & Lung Disease: Unsuccessful Xpert® MTB/RIF results: the Nigerian experience


PResentations:

  July 2017 | AIDSFree Webinar:  SystemOne -Supporting EID & VL Scale Up

July 2017 | AIDSFree Webinar: SystemOne -Supporting EID & VL Scale Up

  July 2017 | USAID:  History of Use of GxAlert in Nigeria  

July 2017 | USAID: History of Use of GxAlert in Nigeria
 

  December 2016 | ASLM:  Importance of Quality Systems and Connectivity

December 2016 | ASLM: Importance of Quality Systems and Connectivity

  December 2016 | ASLM:  Connectivity Needs for Improved Patient Care

December 2016 | ASLM: Connectivity Needs for Improved Patient Care

 
  December 2015 | Union Conference:  GxAlert SMS Improves Patient Enrollment

December 2015 | Union Conference: GxAlert SMS Improves Patient Enrollment

  July 2016 | Cracking the Nut Health Conference:  Cost Effective Technology for TB

July 2016 | Cracking the Nut Health Conference: Cost Effective Technology for TB

  October 2016 | Union Conference:  On the ground experiences and challenges of connected diagnostics GxAlert

October 2016 | Union Conference: On the ground experiences and challenges of connected diagnostics GxAlert

  April 2013 | GLI Partners Meeting:  Faster Response to MDR-TB Through GxAlert

April 2013 | GLI Partners Meeting: Faster Response to MDR-TB Through GxAlert


POSTERS:

  March 2018 | CROI:  Reducing Time for HIV Viral Load Result Delivery to Antiretroviral Treatment Facilities in Malawi.

March 2018 | CROI: Reducing Time for HIV Viral Load Result Delivery to Antiretroviral Treatment Facilities in Malawi.

  October 2016 |  Cost Effective Technology (GxAlert) Improves Drug-Resistance TB Response in Nigeria

October 2016 | Cost Effective Technology (GxAlert) Improves Drug-Resistance TB Response in Nigeria

  December 2016 | ASLM:  Staying in Control of Lab Data in a World of Connected Diagnostics

December 2016 | ASLM: Staying in Control of Lab Data in a World of Connected Diagnostics

  December 2016 | ASLM:  Continuous Quality Improvement (CQI) Through Connected Diagnostics

December 2016 | ASLM: Continuous Quality Improvement (CQI) Through Connected Diagnostics

  December 2016 | ASLM:  Using Connected Diagnostics to Implement the New WHO Shorter MDR Treatment Regimen

December 2016 | ASLM: Using Connected Diagnostics to Implement the New WHO Shorter MDR Treatment Regimen


Case Studies:

  August 2017 | SystemOne:  Swaziland Case Study

August 2017 | SystemOne: Swaziland Case Study

  March 2018 | Twilio Case Study  

March 2018 | Twilio Case Study