Evidence of Impact
Below you will find a list of resources where you can learn more about GxAlert technology and how it's having a disruptive impact on TB programs worldwide. Click graphics below to view complete research document or presentation.
Impact on reporting rates and time to diagnosis:
Connectivity, if skillfully implemented and appropriately utilized, can have a dramatic positive effect on time to treatment, improving patient outcomes and helping to minimize the spread of disease (see article by Natasha Gous 2018)
- In Malawi, paper-based laboratory diagnostic reporting has, on average, a 5%-20% loss in results between the laboratory and clinic. Digital reporting has shown 0% loss of results. For the 15,000 patients in our pilot in Malawi, this means 3,000 patients who weren’t “lost.” (See 2018 CROI poster)
- In Malawi, paper-based reporting of HIV viral load results take an average of 22 days from test completion in the central lab to result receipt at the peripheral clinic. Introduction of our connectivity solution significantly decreased this reporting interval by 94%, from 22 days down to 1 day. This allowed clinicians to identify abnormal results, initiate adherence counselling and switch patients to second line treatment within 1 day of results being available at the laboratory. (See 2018 CROI poster)
- Uganda has shown major improvements in TB reporting rates from GeneXpert testing sites due to the introduction of the GxAlert connectivity solution; 35% reporting from GeneXpert sites in 2016 (prior to connectivity) to 100% reporting from sites post-connectivity (Sama et al, Union 2017- not available online).
In Nigeria, SystemOne’s connectivity platform GxAlert is being used to reduce the turnaround time for reporting of GeneXpert Rifampicin-resistant TB cases to the TB government supervisor, state program manager and national program enrollment officer through automated SMS alerts. Since implementation of the GxAlert SMS system, the proportion of drug-resistant TB patients on treatment has significantly increased from 20% in 2014 to 85% in 2015 (2015 Union oral presentation; article by Mustapha; 2017 Health Finance poster)
Impact on program and fleet management:
Our solutions provide insights into laboratory workflow and workload to ensure optimal use of instruments, assays and shift-workers, error rates, stock-outs and over-stocking of facilities, improving ROI of the instruments and investments in assays/tests.
- By monitoring instrument error rates and error codes centrally, the Ethiopian Public Health Institute has been able to identify sites with high errors and intervene through on-site troubleshooting and refresher training. Since the adoption of GxAlert, national unsuccessful test rate (errors, invalids, no results) have steadily decreased by 6% (Mengesha et al, Union Africa 2017 - not available online).
- Due to the real-time monitoring and immediate feedback provided on the GxAlert system, Bangladesh had decreased their national instrument error rates by 46%; from 6.09% (2015) to 2.81% (2017) (Hossain et al, submitted to Union Oct, 2018).
- Bangladesh is utilizing GxAlert to improve the utilization of machines. The local device distributor and servicing company can now remotely monitor the module status (failures) and take preventive actions, which has led to a significant drop in module replacement time from 5-14 months in 2015 to only 2 weeks in 2017 (Hossain et al, submitted to Union Oct, 2018).
- Based on a 5-country study, SystemOne estimates that 40%-60% of cartridges go to waste because they are unused or expired. Some labs run out of cartridges while others have unused inventory that could be used elsewhere. Since management of inventory on GxAlert, Bangladesh has experienced no stock outs of GeneXpert inventory (Hossain et al, submitted to Union Oct, 2018).